Oxycodone 40mg
Oxycodone 40mg Price range: 295,00€ through 655,00€
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Oxycodone 15mg
Oxycodone 15mg Price range: 292,00€ through 652,00€

Oxycodone 30mg

Price range: 294,00€ through 654,00€

* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Oxycodone HCl 30mg – High-Potency Opioid for Severe Chronic Pain
(Extended-Release Formulation – Reserved for Opioid-Tolerant Patients Only)


⚠️ Critical Safety Notice

  • STRICTLY CONTRAINDICATED for opioid-naïve individuals

  • FOR USE ONLY in patients already taking ≥45mg MEDD (morphine equivalent daily dose)

  • TAMPERING RISK: Must prescribe with abuse-deterrent formulation


Therapeutic Profile

• Schedule II controlled substance (DEA)
• Duration: 12-hour controlled release
• Peak Effect: 4-6 hours post-dose
• Metabolism: Hepatic (CYP3A4/2D6)


FDA-Approved Indications

✔ Around-the-clock cancer pain management
✔ Chronic severe pain in opioid-adapted patients
✔ Palliative care when lower doses fail


Dosing Protocol

  • Minimum Tolerance Requirement:
    ≥45mg oral morphine equivalents/day for ≥1 week

  • Conversion Guide:
    30mg oxycodone ER q12h = 60mg oral morphine/day

  • Administration:
    Swallow whole – never crush, chew, or dissolve

  • Renal Adjustment:
    Reduce frequency to q24h if CrCl <30mL/min


Abuse-Deterrent Features

  • Hardened Tablet Matrix (resists crushing)

  • Viscous Gel Formation if manipulated

  • Brand Examples: OxyContin OP, Xtampza ER


Black Box Warnings

🛑 HIGH ADDICTION POTENTIAL – Abuse may lead to overdose/death
🛑 LIFE-THREATENING RESPIRATORY DEPRESSION
🛑 NEONATAL OPIOID WITHDRAWAL SYNDROME


Prescribing Requirements

• Documented Opioid Tolerance in medical record
• Pain Management Contract signed
• Naloxone Co-Prescription mandatory
• Monthly PDMP Checks required


Identification & Packaging

  • Tablet Markings:
    • OxyContin OP: “OP” on one side, “30” on other
    • Colors vary by manufacturer (e.g., green, gray)

  • Dispensing Limits:
    • 30-day supply maximum
    • No automatic refills

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