Oxycodone 20mg
Oxycodone 20mg Price range: 293,00€ through 653,00€
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Oxycodone 10mg
Oxycodone 10mg Price range: 291,00€ through 651,00€

Oxycodone 15mg

Price range: 292,00€ through 652,00€

* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Oxycodone HCl 15mg – Mid-Range Opioid for Moderate-to-Severe Pain
(Available in Immediate-Release [IR] and Extended-Release [ER] Formulations)


Therapeutic Profile

• Schedule II Controlled Substance (High Abuse Potential)
• Onset/Duration:

  • IR: 15-30 min onset | 4-6 hr duration

  • ER: 1-2 hr onset | 12 hr duration
    • Metabolism: Liver (CYP3A4/2D6) – Caution with inhibitors/inducers


Clinical Indications

✔ Breakthrough Cancer Pain (with ER baseline)
✔ Post-Surgical Pain (IR only, short-term)
✔ Chronic Pain (ER only for opioid-tolerant patients)
✔ Trauma/Injury Pain (IR, ≤5 day supply recommended)


Dosing Guidelines

For OPIOID-NAÏVE Patients (IR only):

  • Not recommended as initial dose – start with 5mg

  • Only after tolerance established: 15mg q4-6h PRN

For OPIOID-TOLERANT Patients:

  • ER: 15mg q12h (must be on ≥30mg MEDD baseline)

  • IR: 15mg q4-6h PRN breakthrough pain

Critical Administration Notes:

  • ER Tablets: Must swallow whole – never crush/chew (risk of fatal overdose)

  • IR Tablets: May be split for dose titration

  • Food Effect: High-fat meals increase ER absorption


Abuse-Deterrent Formulations

  • OxyContin ER 15mg: Round, gray tablet with “OP” on one side

  • Xtampza ER: Capsule formulation (tamper-resistant)

  • IR Options: Oxaydo (nasal abuse-resistant)


Black Box Warnings

⚠️ HIGH ADDICTION/OVERDOSE RISK
⚠️ LIFE-THREATENING RESPIRATORY DEPRESSION (especially with alcohol/benzos)
⚠️ NEONATAL OPIOID WITHDRAWAL SYNDROME


Safety & Monitoring Requirements

• Naloxone Co-Prescription Mandatory
• PDMP Check Before Each Prescription
• Urine Drug Screening for Chronic Use
• Storage: Locked container required
• Max Initial IR Prescription: 3-7 day supply


Special Populations

  • Elderly: Reduce dose by 25-50%

  • Renal Impairment: Avoid ER if CrCl <30mL/min

  • Hepatic Dysfunction: Start with 50% dose

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