Hydrocodone 10/500mg
Hydrocodone 10/500mg Price range: 292,00€ through 652,00€
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Hydrocodone 5-325 mg
Hydrocodone 5-325 mg Price range: 290,00€ through 650,00€

Hydrocodone 10/325mg

Price range: 291,00€ through 651,00€

* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Hydrocodone Bitartrate/Acetaminophen 10mg/325mg – Moderate-to-Severe Short-Term Pain Relief
(Most Commonly Prescribed Opioid-Acetaminophen Combination in the U.S.)


Therapeutic Profile

• Schedule II Controlled Substance (DEA)
• Onset: 20-30 minutes
• Duration: 4-6 hours
• Metabolism: Liver (CYP2D6/3A4 for hydrocodone)


Clinical Indications

✔ Acute musculoskeletal pain (e.g., fractures, severe sprains)
✔ Postoperative pain (dental, minor surgical procedures)
✔ Short-term management (<5 days recommended)
✔ Breakthrough pain in opioid-tolerant patients


Dosing Protocol

For OPIOID-NAÏVE Patients:

  • Start with 1/2 tablet (5mg hydrocodone) q4-6h PRN

  • Max initial dose: 6 tablets/24h (60mg hydrocodone/1,950mg APAP)

For OPIOID-TOLERANT Patients:

  • May require 1 tablet q4h (max 8 tablets/24h = 2,600mg APAP)

Critical Limits:

  • APAP Ceiling: ≤3,000mg/day (chronic) or ≤4,000mg/day (acute)

  • Never Exceed: 3,250mg APAP/24h (FDA limit)


Product Identification

  • White Oval Tablets (generic)

  • Common Imprints:
    • “10/325”
    • “M366”
    • “IP 110”

  • Brand Versions:
    • Norco® (discontinued but still referenced)
    • Vicodin® (original 5/500mg formulation discontinued)


Black Box Warnings

⚠️ ACETAMINOPHEN HEPATOTOXICITY (leading cause of ALF in U.S.)
⚠️ OPIOID ADDICTION/OVERDOSE RISK
⚠️ LIFE-THREATENING RESPIRATORY DEPRESSION


Safety & Monitoring Requirements

• Naloxone Co-Prescription mandatory in most states
• PDMP Check before each prescription
• Renal/Hepatic Adjustment:

  • Reduce dose/frequency in impairment
    • Avoid With:

  • Alcohol

  • Benzodiazepines

  • CYP3A4 inhibitors (e.g., macrolides, azoles)


Prescribing Best Practices

  1. Always start lowest effective dose

  2. Limit initial prescriptions to ≤3 day supply

  3. Use with non-opioid adjuvants (NSAIDs, ice, PT)

  4. Document “lowest necessary quantity” justification


Clinical Alert:
“10/325mg contains 2x the opioid of standard starter doses (5/325mg). Reserve for patients with confirmed opioid tolerance or severe acute pain.”

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