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Vicodin 75/750mg Price range: 292,00€ through 652,00€
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Vicodin 10mg

Price range: 291,00€ through 651,00€

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Vicodin® (Hydrocodone Bitartrate/Acetaminophen) 10mg/300mg – Discontinued Opioid-Analgesic Combination

*(Note: Vicodin brand is no longer manufactured. Current equivalent = Norco 10/325mg)*

⚠️ Critical Safety Update

  • Original Formulation: 10mg hydrocodone + 300mg APAP

  • Status: Discontinued (replaced by lower APAP formulations)

  • Current Standard: Norco 10/325mg

Therapeutic Profile

• Schedule II Controlled Substance (High abuse potential)
• Composition:

  • Hydrocodone 10mg (μ-opioid agonist)

  • Acetaminophen 300mg (non-opioid analgesic)
    • Onset: 20-30 minutes
    • Duration: 4-6 hours

Why Reformulated?

  • FDA 2011 Mandate: All opioid/APAP combos limited to ≤325mg APAP

  • Liver Toxicity Risk:

    • 8 tablets = 2,400mg APAP (near daily max)

    • No safety margin for additional APAP use

Modern Alternatives

Product Hydrocodone APAP Status
Norco 10/325mg 10mg 325mg Available
Hysingla ER 10-120mg 0mg APAP-free
Zamicet 10mg 300mg Liquid form

Dosing Protocol (Historical)

  • Adults: 1 tab q4-6h PRN pain

  • Max Daily APAP: ≤3,000mg (chronic)

  • Never Exceed: 4,000mg APAP/24h

Black Box Warnings

⚠️ ACETAMINOPHEN HEPATOTOXICITY
⚠️ OPIOID ADDICTION/OVERDOSE RISK
⚠️ LIFE-THREATENING RESPIRATORY DEPRESSION

If You Have Old Vicodin 10/300:

  1. Discontinue Use – May be expired/unsafe

  2. Switch to Norco 10/325mg

  3. Monitor LFTs if long-term use

Safety Essentials for Current Prescribing

• Naloxone Co-Prescription required
• PDMP Checks before each Rx
• 7-Day Limit for acute pain
• Avoid With:

  • Alcohol

  • Benzodiazepines

  • CYP3A4 inhibitors

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