Percocet 7.5/325mg – Balanced Opioid Analgesia for Moderate to Severe Pain
Intermediate-strength oxycodone/APAP combination for controlled pain relief
Therapeutic Profile
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Oxycodone HCl: 7.5mg (Schedule II opioid agonist)
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Acetaminophen: 325mg (non-opioid analgesic)
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Duration: 4–6 hours of pain control
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Tmax: 1–1.5 hours post-dose
Clinical Applications
✔ Postoperative pain (e.g., dental surgery, minor orthopedic procedures)
✔ Acute injury management (fractures, severe sprains)
✔ Breakthrough cancer pain (adjunct to long-acting opioids)
✔ Short-term severe pain when NSAIDs are contraindicated
Dosing Guidelines
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Adults (opioid-tolerant): 1 tab q4–6h PRN pain
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Max Daily APAP: ≤3,250mg (≤10 tabs/24hr)
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Opioid-Naive Patients: Start with 5/325mg first
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Renal Impairment: Consider reduced frequency
Risk Mitigation Strategies
⚠️ ABUSE DETERRENT:
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Tablets are crush-resistant (but not abuse-proof)
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Tinted and imprinted for identification
⚠️ MANDATORY MONITORING:
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Assess pain/function at each follow-up
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Check state PDMP before prescribing
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Urine drug screening recommended
⚠️ SAFETY ALERTS:
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Respiratory depression risk (avoid with benzos/alcohol)
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APAP hepatotoxicity (no additional acetaminophen)
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Opioid-induced constipation (stimulant laxatives advised)
Comparative Advantages
→ Stronger than hydrocodone 5/325mg
→ Less sedating than morphine IR
→ More versatile than codeine combinations
→ Lower APAP load than legacy 10/500 formulations
Patient Counseling Points
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“Take only when severe pain occurs”
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“Never share with others”
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“Store locked away from children/pets”
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“Report dizziness or slow breathing immediately”
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“Use stool softeners preventatively”
Prescribing Considerations
▸ First-line for moderate-severe acute pain
▸ Avoid in chronic pain without specialist consultation
▸ Requires Risk Evaluation and Mitigation Strategy (REMS) compliance
▸ Preferred over higher doses for elderly/renal patients
Available as:
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Peach oval tablets (brand)
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White round generics
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Unit-dose packaging for hospitals
