Sibutramine hydrochloride (HCl) is a medication that was primarily used as an appetite suppressant for weight loss. It acts on the central nervous system to promote satiety, helping individuals consume fewer calories. Although it was effective for weight management, its use has been discontinued in many countries due to concerns about cardiovascular risks.
Original Sibutramine HCL Formulations
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Brand Names: Meridia (U.S.), Reductil (Europe), Sibutrex, and others.
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Effects
1. Positive Effects
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Reduced appetite and caloric intake.
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Modest weight loss when combined with lifestyle changes.
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Improved metabolic markers in some individuals.
2. Negative Effects
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Common Side Effects:
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Dry mouth, headache, constipation, and insomnia.
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Increased heart rate and blood pressure.
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Severe Side Effects:
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Cardiovascular risks, including heart attack and stroke.
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Mood changes, anxiety, and potential for serotonin syndrome.
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Usage
1. Primary Use
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Obesity Management: Prescribed to aid in weight loss for individuals with a body mass index (BMI) ≥30 kg/m² or ≥27 kg/m² with obesity-related conditions (e.g., diabetes, hypertension).
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Functioned as part of a comprehensive weight-loss plan, including diet and exercise.
2. Mechanism of Action:
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Sibutramine inhibits the reuptake of serotonin, norepinephrine, and dopamine, increasing their levels in the brain. This enhances feelings of fullness and reduces appetite.
