Sibutramine HCL

CAS Number:

106650-56-0

Batch Molecular Formula:

C17H26ClN

Batch Molecular Weight:

279.85 g/mol

Physical Appearance:

White to Off White Crystalline Powder

Solubility:

Soluble in Water

Storage:

Store at RT

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgment of your healthcare professional.

Sibutramine hydrochloride (HCl) is a medication that was primarily used as an appetite suppressant for weight loss. It acts on the central nervous system to promote satiety, helping individuals consume fewer calories. Although it was effective for weight management, its use has been discontinued in many countries due to concerns about cardiovascular risks.

Original Sibutramine HCL Formulations

Brand Names: Meridia (US), Reductil (Europe), Sibutrex, and others.

Delphis Pharma – Leading Sibutramine Manufacturer & Contract Manufacturer in India & Global Markets

Delphis Pharma is a trusted manufacturer and contract manufacturer of Sibutramine in India and international marketsWe offer custom manufacturing solutions, competitive pricing, and seamless logistics tailored to your needs. Partner with us for high-quality Sibutramine production and global supply.

Effects

1. Positive Effects

Reduced appetite and caloric intake.
Modest weight loss when combined with lifestyle changes.
Improved metabolic markers in some individuals.

2. Negative Effects

Common Side Effects:
- Dry mouth, headache, constipation, and insomnia.
- Increased heart rate and blood pressure.
Severe Side Effects:
- Cardiovascular risks, including heart attack and stroke.
- Mood changes, anxiety, and potential for serotonin syndrome.

Usage

1. Primary Use

Obesity Management: Prescribed to aid in weight loss for individuals with a body mass index (BMI) ≥30 kg/m² or ≥27 kg/m² with obesity-related conditions (eg, diabetes, hypertension).
Functioned as part of a comprehensive weight-loss plan, including diet and exercise.

2. Mechanism of Action:

Sibutramine inhibits the reuptake of serotonin, norepinephrine, and dopamine, increasing their levels in the brain. This enhances feelings of fullness and reduces appetite.

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