Oxycodone 5mg

Oxycodone HCl 5mg – Low-Dose Opioid for Moderate Pain Control
(Available in Immediate-Release [IR] Formulation)

Therapeutic Profile

• Schedule II Controlled Substance (High caution required)
• Onset: 15-30 minutes
• Duration: 4-6 hours
• METABOLISM: Liver (CYP3A4/2D6) – Check for drug interactions

Clinical Indications

✔ First-line for opioid-naïve patients with acute pain
✔ Post-procedural pain (dental surgery, minor procedures)
✔ Step-down dosing for opioid taper
✔ Breakthrough pain in palliative care (with baseline ER opioid)

Dosing Guidelines

For OPIOID-NAÏVE Patients:

• Start with 2.5-5mg q4-6h PRN pain

• Max initial dose: 15mg/24 hours

For ELDERLY/DEBILITATED:

• Reduce to 2.5mg initial dose

• Extend interval to q6-8h

Special Cases:

• Renal impairment: Avoid in CrCl <30mL/min

• Hepatic dysfunction: Reduce frequency

Product Identification

• Generic IR:

  • White, round tablets (often scored)

  • Imprints vary (e.g., “5” or “K 56”)

• Brand Options:

  • Oxaydo® (abuse-deterrent formulation)

Black Box Warnings

⚠️ ADDICTION/OVERDOSE RISK – Even at low doses
⚠️ LIFE-THREATENING RESPIRATORY DEPRESSION
⚠️ NEONATAL WITHDRAWAL with pregnancy use

Safety Protocols

• Naloxone co-prescription required in most states
• 3-7 day limit for acute pain prescriptions
• Storage: Locked container mandatory
• Avoid with:

• Alcohol

• Benzodiazepines

• Other CNS depressants

Prescribing Best Practices

1. Always start lowest effective dose

2. Reassess after 48 hours

3. Taper if used >5 days

4. Document MEDD calculations

Clinical Pearl:
“5mg may seem insignificant but can cause fatal respiratory depression in opioid-naïve patients. Always verify tolerance status.”