Therapeutic Profile (Historical Use)
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Schedule II Controlled Substance (High potential for abuse/dependence)
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Composition:
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Hydrocodone 10mg (opioid agonist)
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Acetaminophen 500mg (non-opioid analgesic)
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Onset: ~30 minutes
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Duration: 4–6 hours
Reason for Discontinuation:
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Acetaminophen Toxicity Risk:
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6 tablets = 3,000mg APAP (daily max for chronic use)
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8 tablets = 4,000mg APAP (acute liver failure risk)
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FDA Mandate (2011): All opioid/APAP combos limited to ≤325mg APAP per dose
Modern Alternatives:
| Product | Hydrocodone | APAP | Status |
|---|---|---|---|
| Norco 10/325mg | 10mg | 325mg | Available |
| Hysingla ER | 10–120mg | 0mg | APAP-free |
| Vicodin HP | 10mg | 300mg | Rare |
Safety Considerations:
✔ Never exceed 3,000mg APAP/day (chronic) or 4,000mg/day (acute)
✔ Avoid alcohol (increases liver toxicity risk)
✔ Watch for hidden APAP in cold/flu medications
If You Encounter 10/500mg Tablets:
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Do NOT use – May be counterfeit/expired
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Switch to current formulations (e.g., Norco 10/325mg)
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Consult a doctor for proper pain management
Available Alternatives:
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For short-term pain: Norco 10/325mg
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For chronic pain: Hysingla ER (APAP-free)
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Non-opioid options: NSAIDs, gabapentin, physical therapy
Prescribing Note:
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Hydrocodone combos are Schedule II (strict regulations apply)
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Naloxone co-prescription recommended
