Percocet 10/325mg – Dual-Action Pain Relief for Moderate to Severe Acute Pain
Combination opioid/acetaminophen formula for effective short-term pain management
Key Features:
✔️ Powerful Analgesic – 10mg oxycodone (Schedule II opioid)
✔️ Enhanced Effect – 325mg acetaminophen boosts pain relief
✔️ Immediate Release – Fast-acting for acute pain episodes
✔️ 4-6 Hour Duration – Balanced therapeutic window
Clinical Indications:
• Post-surgical pain
• Major injury recovery
• Severe dental procedures
• Trauma-related pain
• Cancer pain (as part of regimen)
Dosing Protocol:
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Adults: 1 tablet every 4-6 hours as needed for pain
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Max Daily Limit: 6 tablets/24hr (≤4g acetaminophen)
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Short-Term Use Only – Typically ≤5 days for acute pain
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Take with Food – Minimizes GI discomfort
Safety Warnings (Black Box):
⚠️ HIGH ADDICTION POTENTIAL – Strictly follow prescribing instructions
⚠️ Respiratory Depression Risk – Especially with other CNS depressants
⚠️ Acetaminophen Toxicity – Do not exceed 3250mg/day (chronic use)
⚠️ NEVER Crush/Chew – Avoid rapid release/abuse potential
Patient Considerations:
→ Requires opioid-naive patients to start with lower doses (2.5/325 or 5/325)
→ Not for chronic pain management without special protocols
→ Must store securely to prevent misuse/theft
→ Always use with non-opioid adjuvants when possible
Monitoring Requirements:
• Regular physician follow-ups
• Pain diary documentation
• Bowel regimen for constipation
• Respiratory rate checks
Discontinuation Protocol:
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Taper gradually to prevent withdrawal
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Never stop abruptly after prolonged use
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Watch for rebound pain
Available Formats:
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Round white tablets (imprint varies by manufacturer)
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100-count bottles with safety cap
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Blister packs for controlled dispensing
Prescription Limitations:
▸ Requires written prescription (no refills) in most states
▸ Mandatory PDMP checks before dispensing
▸ Often requires pain management contract
This medication should only be used under strict medical supervision as part of a comprehensive pain management plan.
