Percocet 2.5/325mg

Percocet 2.5/325mg – Ultra-Low-Dose Opioid Initiation Therapy

The Safest Starting Point for Opioid-Naive Patients

Therapeutic Profile

• Micro-dose oxycodone: 2.5mg (lowest available combo strength)

• Standard acetaminophen: 325mg

• Duration: 3–4 hours of analgesia

• Peak effect: 45–60 minutes post-dose

Specialized Clinical Uses

✔ Opioid initiation therapy for elderly/frail patients
✔ Pediatric post-op pain (12+ years, off-label)
✔ Step-down titration for opioid weaning
✔ Breakthrough pain in hypersensitive patients
✔ Renal/hepatic impairment cautious dosing

Precision Dosing Guidelines

• Adults (opioid-naive): 1/2–1 tab q6h PRN (max 3g APAP/day)

• Geriatric: Start with 1/2 tab (1.25mg oxycodone)

• Titration: May increase to 5/325mg after 48hr if needed

• APAP Monitoring: ≤9 tabs/24hr (under 3g threshold)

Safety Innovations

⚠️ Overdose Protection:

• 40% lower opioid load than standard 5/325mg starter dose

• Built-in APAP ceiling safety

⚠️ Unique Identification:

• White round tablets with “2.5” imprint

• Unit-dose packaging available

Clinical Advantages

→ Lower respiratory depression risk vs. standard doses
→ Ideal for opioid risk mitigation programs
→ Enables finer dose titration
→ Reduced constipation/SEs in vulnerable populations

Essential Counseling Points

• “This is extra-strength Tylenol with a tiny opioid boost”

• “Never combine with other APAP products”

• “Report drowsiness/dizziness immediately”

• “Use with non-opioid adjuvants (NSAIDs, ice, etc.)”

Prescribing Scenarios

▸ First opioid ever prescribed to patient
▸ Transitioning from IV opioids post-discharge
▸ Special populations:

• Cachectic cancer patients

• COPD/sleep apnea sufferers

• Chronic kidney disease (Stage 3+)

Comparison to Alternatives