Vicodin 10mg

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* The information on this page is a summary and is not intended to cover all available information about this medication. It does not cover all possible uses, directions, precautions, drug interactions or adverse effects and is not a substitute for the expertise and judgement of your healthcare professional.

Vicodin® (Hydrocodone Bitartrate/Acetaminophen) 10mg/300mg – Discontinued Opioid-Analgesic Combination

*(Note: Vicodin brand is no longer manufactured. Current equivalent = Norco 10/325mg)*

⚠️ Critical Safety Update

Original Formulation: 10mg hydrocodone + 300mg APAP
Status: Discontinued (replaced by lower APAP formulations)
Current Standard: Norco 10/325mg

Therapeutic Profile

• Schedule II Controlled Substance (High abuse potential)
• Composition:

Hydrocodone 10mg (μ-opioid agonist)
Acetaminophen 300mg (non-opioid analgesic)
• Onset: 20-30 minutes
• Duration: 4-6 hours

Why Reformulated?

FDA 2011 Mandate: All opioid/APAP combos limited to ≤325mg APAP
Liver Toxicity Risk:
- 8 tablets = 2,400mg APAP (near daily max)
- No safety margin for additional APAP use

Modern Alternatives

Product	Hidrocodona	APAP	Status
Norco 10/325mg	10mg	325mg	Available
Hysingla ER	10-120mg	0mg	APAP-free
Zamicet	10mg	300mg	Liquid form

Dosing Protocol (Historical)

Adults: 1 tab q4-6h PRN pain
Max Daily APAP: ≤3,000mg (chronic)
Never Exceed: 4,000mg APAP/24h

Black Box Warnings

⚠️ ACETAMINOPHEN HEPATOTOXICITY
⚠️ OPIOID ADDICTION/OVERDOSE RISK
⚠️ LIFE-THREATENING RESPIRATORY DEPRESSION

If You Have Old Vicodin 10/300:

Discontinue Use – May be expired/unsafe
Switch to Norco 10/325mg
Monitor LFTs if long-term use

Safety Essentials for Current Prescribing

• Naloxone Co-Prescription required
• PDMP Checks before each Rx
• 7-Day Limit for acute pain
• Avoid With:

Alcohol
Benzodiazepines
CYP3A4 inhibitors

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