Oxicodonă 40 mg

Oxycodone HCl 40mg – High-Potency Opioid for Severe Refractory Pain
(Extended-Release Formulation Only – Never for Immediate Use)

Critical Safety Alert

⚠️ ABSOLUTELY CONTRAINDICATED in opioid-naïve patients
⚠️ NUMAI PENTRU UTILIZARE in opioid-tolerant patients (≥60mg MEDD for ≥1 week)
⚠️ TAMPER-RESISTANT formulation required by FDA

Profil terapeutic

• Anexa II substanță controlată
• ER Mechanism: Eliberare controlată timp de 12 ore
• Bioavailability: 60-87% (higher than morphine)
• Efect de vârf: 4-5 hours post-dose

Strict Indications

✔ Cancer pain la pacienții adaptați la opioide
✔ Durere cronică with documented tolerance
✔ Îngrijiri paliative cases with failed lower doses

Protocol de dozare

• Must Confirm Tolerance:
  ≥60mg oral morphine equivalents daily for ≥1 week

• Initial Conversion:
  30mg oxycodone ER q12h = 90mg oral morphine/day

• Never Crush/Chew:
  Avoid deadly rapid release

• Ajustare renală:
  Reduce dose by 50% if CrCl <60mL/min

Caracteristici de descurajare a abuzurilor

• Hardened Matrix: Resists crushing (OxyContin OP)

• Gel Formation: Snorting prevention

• FDA-Mandated REMS: Prescriber/pharmacist certification

Avertismente Black Box

🛑 ADDICTION/OVERDOSE: High abuse potential
🛑 NEONATAL WITHDRAWAL: Pregnancy risks
🛑 DEPRESIE RESPIRATORIE CARE AMENINȚĂ VIAȚA

Patient Requirements

• Opioid Treatment Agreement semnat
• Monthly Prescriptions (no refills)
• Co-rețetă de Naloxonă obligatoriu
• Urine Drug Screening compliance

Available Formulations

• Brand (OxyContin): Round bi-convex tablets

• Generics: Must include FDA-approved AD properties

• Identification:
  • “OP” on one side, “40” on reverse
  • Color varies by manufacturer