Diazepam 10mg

Diazepam 10mg – Potent Anxiolytic & Muscle Relaxant
Fast-acting benzodiazepine for acute anxiety, seizures, and muscle spasms

Core Therapeutic Effects

✔ Anxiolytic: Rapid anxiety/panic attack relief (30-60min onset)
✔ Anticonvulsant: IV/PRN for active seizures
✔ Myorelaxant: Effective for acute muscle spasms
✔ Sedative: Pre-procedure anxiolysis

Clinical Applications

• Acute anxiety episodes (short-term use)
• Alcohol withdrawal syndrome (CIWA protocol)
• Muscle spasm relief (e.g., back injuries)
• Status epilepticus (IV formulation)
• Preoperative sedation

Dosing Guidelines

• Adults (anxiety): 2-10mg 2-4x daily (max 30mg/day)

• Muscle spasms: 5-10mg 3-4x daily

• Elderly: Half adult dose (2-5mg)

• Half-life: 20-100 hours (active metabolites)

Unique Pharmacokinetics

→ Prolonged duration due to active metabolites
→ Lipophilic: Crosses BBB rapidly
→ IM absorption: Unreliable (prefer IV/PO)

Black Box Warnings

⚠️ ADDICTION RISK: Schedule IV controlled substance
⚠️ RESPIRATORY DEPRESSION: Potentiated by opioids/alcohol
⚠️ WITHDRAWAL SYNDROME: Taper after >2 weeks use

Safety Considerations

• Avoid in: Severe COPD, sleep apnea, acute glaucoma
• Monitor for: Paradoxical reactions in elderly
• Disposal: DEA take-back programs only

Available as:

• Blue 10mg tablets (scored)

• IV/IM injection (5mg/mL)

• Rectal gel (for seizures)